CDX2 and adenocarcinoma: It remains unclear whether milieu factors, inflammation or infections like those known in the upper gastro-intestinal tract [14, 15] might trigger in the endometrium the aberrant expression of CDX2 and the downregulation of hormone receptors and PAX8 as Müllerian markers, but these lesions can be discussed as possible precursors of intestinally differentiated adenocarcinomas of the uterine corpus.