CX3CR1 and chronic obstructive pulmonary disease: The median number of marginated CX3CR1+ cells per μm vessel circumference were significantly greater in NS (83.9 x10-4/μm) and S (31.5 x10-4/μm) compared to COPD (1.5 × 10-4/μm;p < 0.01 and p < 0.05 respectively).