Tubular biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule 1 (K1M1) N-acetyl-B-(D) glucosaminidase (NAG), advanced glycation end products (AGES), namely pentosidine had been related to the status of microalbuminuria and appeared to be not a proper index for the early detection of diabetic kidney disease due to its relationship with the insensitive marker microalbuminuria [14–18]. This evidence concerns the gene LCN2 and diabetic kidney disease.