For the identification of the function of STIM1 in HNSCC, TSCCA and Hep2 were transfected with STIM1-siRNA to downregulate STIM1 expression, and Tb3.1 was transfected with GV144-STIM1 to upregulate STIM1 expression. The gene discussed is STIM1; the disease is head and neck squamous cell carcinoma.