To date, defects in four of them have been linked to different types of canine EB: a premature stop codon in PKP1 causing ectodermal dysplasia-skin fragility syndrome [5], a nonsense mutation in PLEC causing EBS [6], an insertion in LAMA3 causing JEB [7] and a missense mutation in COL7A1 causing a mild form of DEB [8]. Here, COL7A1 is linked to Dystrophic epidermolysis bullosa.