In a study by Wang and colleagues on 154 patients with acute ischemic stroke and 2890 subjects from the population-based Beijing Eye Study as control group, acute stroke was significantly associated with a thinning of the RNFL (P<0.001; odds OR: 6.23) after adjusting for older age, male sex, arterial hypertension, diabetes mellitus, and higher concentration of the C-reactive protein [8]. The gene discussed is CRP; the disease is Hypertension.