The ISI, calculated with C-peptide deconvolution over the first 30 min of the post-meal period, also shown the diminished insulin secretion capacity of MODY3 β-cells (median [IQR]: 15.0 [11.6; 19.6]) compared to controls (42.1 [38.2; 64.8]; P<0.001) and T2D (44.7 [37.3; 85.2]; P<0.03). This evidence concerns the gene INS and type 2 diabetes mellitus.