In SOST-/- mice, for instance, it has been shown that kidney repair after unilateral urether obstruction is delayed [6] whilst in animal models of early CKD, incomplete recovery from acute kidney injury led to increased expression of Wnt inhibitors including DKK1 and sclerostin in the injured kidney and to increased levels in the systemic circulation [7]. Here, DKK1 is linked to chronic kidney disease.