ACTG1 and Beckwith-Wiedemann syndrome: The DNM identified in ACTG1 (NM_001199954.1; MIM# 102560) in COL5231458 (family 12; c.209C>T (p.(Pro70Leu), RNA not analyzed)) represented a strong candidate because DNM in the ubiquitous cytoplasmic actins (encoded by ACTB and ACTG1) cause Baraitser–Winter syndrome (BWS) with OC as a prominent feature (MIM# 243310 and 614583) (Di Donato et al., 2014; Rivière et al., 2012).