BGLAP and cholestasis: Bone loss was an early event in hepatic cholestasis, as 85% of the children were classified as Child-Pugh A and the other 15% were classified as Child-Pugh B. After 3 years, more consistent incremental increases in the serum levels of osteocalcin were observed in the control group (76%) than in children with cholestasis (31%) 11.