The diagnosis of acromegaly is based on findings such as panhypopituitarism, neuro-ophthalmic symptoms and signs due to compression of adjacent structures as the tumor grows and confirmed by increased GH and insulin-like growth factor 1 (IGF-1) levels, non-suppression of GH during an oral glucose tolerance test (OGTT) and magnetic resonance imaging of the sella turcica 1,2,4. The gene discussed is IGF1; the disease is acromegaly.