However, this function when utilized by cancer cells, may lead to the effluxing of many drugs and enhanced chemoresistance.15 PRKCE, a member of protein kinase C (PKC) family, is a serine- and threonine-specific protein kinase that actively participate in promoting drug resistance through phosphorylating a variety of protein targets, such as P-gp, ATF2, PI3K, Stat3, and Erk.16, 17. Here, PGP is linked to cancer.