STAT3 and neoplasm: It was also reported to have other pharmacological effects including anticardiovascular diseases,18 anti-inflammation,19, 20 neuron protection21 and antiproliferation of cancer cells.22 We recently observed that CTS suppressed the proliferation of human MG cells T98G and U87 through inhibition of STAT3 signaling pathway.23 However, little is known about its in vivo effect on tumor, particularly MGs.