ITPR1 and acute myeloid leukemia: To further investigate whether wogonoside exerts its effects on cell differentiation via modulating DNA transcription, PLSCR1 and IP3R1 mRNA levels in #2 primary AML cells were examined in the presence of wogonoside at a concentration known to induce differentiation (150 μM) for 0, 12, 24, 48, 72 and 96 h.