ITPR1 and leukemia: The nuclear-localized PLSCR1 specifically binds to a segment of the 5′-promoter of IP3R1 in a nucleotide sequence-specific manner, enhancing transcription of this gene.23 IP3R1 is known to have a central role in IP3-mediated mobilization of intracellular Ca2+ stores from the ER of diverse cells and is required for cell growth, maturation and differentiation.23, 28, 29 In our study, IP3R1 was detected in CD45+ cells, which were sporadically distributed in BM of wogonoside-treated AML-bearing NOD/SCID mice, suggesting it may be associated with wogonoside’s anti-leukemia effects.