CDKN1B and acute myeloid leukemia: Previous studies have demonstrated that p27Kip1 and p21Cip1 are required for leukemic cell differentiation.32, 33, 34 Moreover, PLSCR1 induction significantly elevated p27Kip1 protein by inhibiting its degradation and increases p21Cip1 by increased transcription and reduced degradation, when c-Myc protein level can be decreased.12 Consistently, during wogonoside-induced myeloid differentiation of primary AML cells, significant upregulation of p21Cip1 and p27Kip1 expression was observed, and the c-Myc level was significantly decreased.