ITPR1 and acute myeloid leukemia: Our previous study demonstrated that wogonoside promotes translocation of PLSCR1 into nucleus and facilitates its binding to the IP3R1 promoter region in U937 and HL-60 cells.7 Similar results were observed in primary AML cells, wogonoside enhanced the DNA-binding activity of PLSCR1 to the IP3R1 promoter region in #2 primary AML cells treated with 150 μM wogonoside for 48 h (Figure 2a).