Ca2+ acts as a pervasive intracellular second messenger that participates in essential biological processes, including secretion, cell proliferation, differentiation and motility.25 In this study, we showed that wogonoside stimulates the differentiation of primary AML cells via a mechanism involving the PLSCR1-IP3R1-Ca2+ pathway. This evidence concerns the gene ITPR1 and acute myeloid leukemia.