Furthermore, similar to the results of sample #2, expression levels of IP3R1, p21Cip1 and p27Kip1 were all increased and c-Myc markedly inhibited after treatment of wogonoside for 96 h in another eight AML samples (#4, #5, #6, #14, #16, #17, #18 and #19) whose PLSCR1 expression levels were markedly upregulated by wogonoside (Figure 2f). This evidence concerns the gene CDKN1B and acute myeloid leukemia.