To further define the regulatory effect of PLSCR1-IP3R1 signaling activation on wogonoside-induced differentiation of primary AML cells, PLSCR1 siRNA (#1, #2) was used to analyze the expression of PLSCR1-IP3R1-related cell cycle and differentiation proteins in #2 and #19 primary AML cells. This evidence concerns the gene ITPR1 and acute myeloid leukemia.