PLSCR1 and acute myeloid leukemia: It is known that PLSCR1 is imported into the nucleus where it binds genomic DNA.21 Indeed, nuclear translocation of PLSCR1 was observed after treatment with wogonoside for 48 h in primary AML cells when expression of PLSCR1 was significantly upregulated, indicating that expression upregulation and nuclear translocation of PLSCR1 may be the common cause of differentiation induction.