CDKN1A and acute myeloid leukemia: Moreover, in primary AML cells from samples #2 and #19, wogonoside exerted significant effects on several cycle- and differentiation-related proteins, including p21Cip1 and p27Kip1 upregulation and c-Myc downregulation, which could be reversed by PLSCR1 silencing (Figures 3d, e, Supplementary Figures 1c and d).