Furthermore, a 3-day administration of Dox did not influence the proliferation curves of APL cells in Neo-3G mice but did inhibit the proliferation of APL cells in Irf8-3G mice (Figure 5e), which was accompanied by a reduction of leukemia burden (Figure 5f), a promoted differentiation to c-Kit+CD11b++ mature APL cells (Figure 5g). This evidence concerns the gene ITGAM and acute promyelocytic leukemia.