To further enrich the real dysregulated genes in immature APL cells from this pool, we then overlapped these genes with the pool of PML/RARα target genes.10 The observation that the expressions of only ~10% of these repressed genes were significantly reversed by ATRA or ATO indicated that ATRA or ATO was unable to correct all of the transcription repression resulting from PML/RARα. The gene discussed is PML; the disease is acute promyelocytic leukemia.