Thus, the CHCHD4 import pathway is being revealed as a therapeutic target for preventing and treating neonatal HI brain injury, and for this reason, future investigations will be necessary for the characterization of the metabolic basis of the neuroprotection provided by the downregulation of CHCHD4 and for the identification of the specific set of CHCHD4 substrates that could play key roles in the observed phenomenon.29 Here, CHCHD4 is linked to injury.