Our results in the breast gland are consistent with other publications where PTP1B inhibition resulted in apoptosis in non-small cell lung cancer cells22 and susceptibility to anoikis in colorectal cancer cells.32 We show here that the cell death induced by inhibition/knockdown of PTP1B and CPT-induced apoptosis demonstrates morphology representative of anoikis and classical apoptosis, respectively. This evidence concerns the gene PTPN1 and colorectal cancer.