The relationship between p62 accumulation and pathogenesis of disease has previously been well discussed.15, 33, 34, 35 p62 has been identified as a common component of ubiquitin-containing protein aggregates, known as inclusion bodies in alcoholic hepatitis and steatohepatitis.35 The inclusion bodies have also been found in neurodegenerative diseases, such as Parkinson’s disease and amyotrophic lateral sclerosis.33, 34 Reduction of autophagic activity might contribute to the generation of inclusion bodies in these diseases. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.