The degradation of p62 is often used as an indicator of autophagy.44 BCM induced increases in expression of p62 mRNA at 3 h (Figure 6h) and in p62 protein expression at 6 h (Figure 6i), which is then followed by decreases in p62 protein expression at 12 and 24 h suggesting activation of autophagy pathways and clearance of p62 (Figure 6i). Here, SQSTM1 is linked to blue cone monochromacy.