EIF2A and early-onset autosomal dominant Alzheimer disease: Certain neurodegenerative conditions, such as Alzheimer’s disease, are characterized by increased levels of p-eIF2α in the brain;16 this can be a response to accumulation of misfolded proteins, proteasome inhibition and mild oxidative stress.28 It is feasible that such conditions of chronically increased eIF2α phosphorylation may affect SG formation.