Of particular interest, HF treatment pronouncedly enhanced the expression level of Atg7 under nutrient-rich condition, whereas decreasing the mRNA level of Atg7 in CRC cells under nutrient-poor condition, but Atg5, Atg10, and Atg12 were not significantly altered upon HF treatment (Supplementary Figure S3). The gene discussed is ATG5; the disease is colorectal carcinoma.