They showed near-infrared fluorescent imaging in vivo as well as ex vivo and observed that 10-dioctadecyl-3,3,30,30-tetramethylindodicarbocyanine-4-chlorobenzene-sulfonate salt (DiD)-loaded LyP-1-PM (LyP-1-PM-DiD) showed preferential accumulation in the tumor than PM-DiD (as shown in Figure 4). The gene discussed is PTPN22; the disease is neoplasm.