ORAI1 and Autoimmunity: Because STIMs perform several additional functions such as regulation of calcium selectivity of ORAI1 channels (McnallyMcNally et al., 2012) as well as inhibition of voltage-gated calcium channel Cav1.2 (Wang et al., 2010; Park et al., 2010), role of sustained calcium influx or store-operated calcium entry (SOCE) in the development of Tregs and autoimmunity remains correlative (Oh-Hora et al., 2008, 2013).