However, ablation of STIMs, but not ORAIs, affects thymic development of Tregs (Oh-Hora et al., 2013; McCarl et al., 2010) and ablation of STIMs, but not ORAI1, results in multi-organ autoimmunity in mice and humans (Oh-Hora et al., 2008; McCarl et al., 2010; Picard et al., 2009). This evidence concerns the gene ORAI1 and Autoimmunity.