CD4 and neoplasm: While its ablation inhibits Foxp3 Treg development, its inactivation is necessary for Treg activation, homing and tumor infiltration (Kerdiles et al., 2010; Luo et al., 2016). Therefore, future analyses of Napahyh/hyh mice will help in evaluating the consequences of simultaneous inhibition of NFAT and mTORC2-dependent signaling pathways on CD4 T cell homeostasis, differentiation and function in specific physiological and disease contexts in vivo.