Our patients’ unusual TMPRSS6 genotype, the clinical history, and the weak response to oral iron therapy resemble other IRIDA cases.6,8,10,11 For example, Pellegrino et al demonstrated in a family case study that one TMPRSS6 gene mutation in combination with 2 or more SNPs can clinically present as IRIDA.11 This evidence concerns the gene TMPRSS6 and IRIDA syndrome.