Genetic studies of the TMPRSS6 gene revealed, in both patients, the presence of heterozygosity of 3 SNPs (single nucleotide polymorphisms), D521D, V736A, and Y739Y, already described associated to higher risk of developing iron deficiency anemia.6,7 In addition to these SNPs, a novel mutation corresponding to a substitution (A>T) in the beginning of intron 11 (c.1396+4 A>T) of the TMPRSS6 gene was also observed. The gene discussed is TMPRSS6; the disease is Iron deficiency anemia.