FOXO3 and central nervous system cancer: The broad-ranging metabolic effects of fenofibrate on glioma cells are associated with lowered cell growth, due to FOX01/p27-induced G0/G1 arrest, and increased apoptotic cell death caused by FOXO3a-activated transcriptional activation of the apoptotic initiator protein Bim (Wilk et al., 2012; Han D. F. et al., 2015).