Platelet MVs aggravate LPS-induced damage of pulmonary endothelial cells (Xie et al., 2015), increase the adhesion of monocytes to endothelial cells (Barry et al., 1998), and induce IL-6 and IL-8 in an IL-1β dependent fashion in synovial joints of rheumatoid arthritis (RA) patients (Boilard et al., 2010). This evidence concerns the gene IL1B and rheumatoid arthritis.