In addition, the transcriptional regulator High mobility group box protein 1 (HMGB1), normally located in the cytosol, is released during necrosis and contributes to inflammation e.g., in acute lung injury (Kim et al., 2005), and one of the main exocytic routes of HMGB1 is via exosomes (Liu et al., 2006). Here, HMGB1 is linked to injury.