VEGFA and central nervous system leukemia: For example, based on our current therapeutic arsenal and understanding of the genes, pathways, and molecules implicated in the pathophysiology of CNS leukemia (Table 1), potential approaches for augmenting CNS-directed therapy include (i) neutralizing or blocking antibodies directed against VEGF (bevacizumab), CCR7, or other adhesion molecules, (ii) Mer tyrosine kinase inhibitors in the setting of a t(1;19), or (iii) metabolic/mitochondrial modulation.