SNCA and synucleinopathy: Importantly, in addition to the traditional α-synuclein-containing pathological inclusions, the development of several synucleinopathies is accompanied by the appearance of α-, β-, and γ-synuclein-positive vesicular-like lesions at the presynaptic axon terminals in the hippocampal dentate, hilar, and CA2/3 regions100.