ATP6V0A2 and ovarian carcinoma: It has been shown that proton pump inhibitors induce apoptosis in human B-cell tumors through a caspase-independent mechanism38.The apoptosis-inducing effects of anti-RTF monoclonal antibody on ovarian carcinoma cells was assessed using Annexin V-FITC assay, and the J774A1 macrophage cell line incubated with anti-RTF showed a complete inhibition of surface ATPase activity39 (US patent, US 7211257 B2).