PLAT and Stroke: Since 2015, there have been five prospective randomized clinical trials showing efficacy of endovascular thrombectomy in addition to standard management, typically r-tPA, in improving outcomes of acute ischemic stroke patients with proximal internal carotid artery (ICA) or middle cerebral artery (MCA) occlusions, moderate to severe stroke severity, and presenting within 12 hours of symptom onset8–12.