The recently published ENCHANTED trial investigated low-dose r-tPA (0.6 mg/kg versus 0.9 mg/kg) for patients with acute ischemic stroke and showed that there was a reduction in mortality and symptomatic intracerebral hemorrhage with a lower dosage when compared to the standard-dosage r-tPA, but this benefit was offset by an increased rate of disability at 90 days in the low-dose group. This evidence concerns the gene PLAT and intracerebral hemorrhage.