Specifically, both the strong excitatory projections from the Ctx to the SRN and the slow kinetics of GABAB synapses along the TRN-SRN pathway are believed to be critical pathological factors in absence seizures (Destexhe, 1998; Robinson et al., 2002; Breakspear et al., 2006; Marten et al., 2009a,b; Han et al., 2012). Here, CYP27A1 is linked to Generalized non-motor (absence) seizure.