During a viral infection, NF-κB gets activated and mediates colocation of the IFN-β gene locus (9p21.3) with three distant NF-κB-bound genomic loci, allele of number 21 (4p13), number 14 (9q33), and number 9 (18q21) [32]. This evidence concerns the gene NFKB1 and viral infectious disease.