In contrast to these models of immunomodulation by helminth infection/helminth Ag, we found no differences in the proportion of IL-10+FOXP3+CD4+, IL-10+CD4+ or IL-10+CD4− cells in the dLNs of any of the mice indicating that this is not a mechanism employed by SMA-treated DCs to down-regulate CIA. The gene discussed is CD4; the disease is helminthiasis.