HRAS and neoplasm: Although the sig-pos-AFD enriched genes are largely tumor suppressive, HRAS and ERBB2, which are as well-known canonical oncogenes, are observed to be significantly enriched with sig-pos-AFD missense mutations (P value of 2.37 × 10−09 in HNSC and 9.03 × 10−4 in STAD, respectively; Fig. 5).