As topical application of honokiol prevents UVB-induced skin tumor growth and multiplicity in laboratory animals15, 16, we tested whether treatment of mice with honokiol in a hydrophilic topical formulation protects against UVB-induced suppression of the CHS response to the skin contact sensitizer, 2, 4-dinitrofluorobenzene (DNFB). The gene discussed is LYST; the disease is skin neoplasm.