Interestingly, the C1.2 linear epitope was identified in epitope mapping studies of the RV144 Thai trial, and plasma IgA binding to the corresponding C1 peptide covering the entire epitope region (C1_104.AE [MQEDVISLWDQSLKPCVKLTPLCV]) correlated with an increased risk of HIV-1 infection (i.e., decreased vaccine efficacy) in the secondary/exploratory immune correlate analysis of the trial (20). The gene discussed is CD79A; the disease is HIV-1 infection.