Since degeneration of motor nerve terminals appears to play an important role in pathogenesis of both patients and animal models of ALS (Fischer et al, 2004; Murray et al, 2010; Dadon‐Nachum et al, 2011; Valdez et al, 2012; Bruneteau et al, 2015), in the present study we examined whether DOK7 gene therapy ameliorates pathology in a mouse model of ALS. Here, DOK7 is linked to amyotrophic lateral sclerosis.