SLC1A3 and amyotrophic lateral sclerosis: Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is a neuroprotective drug approved for amyotrophic lateral sclerosis [45] and activates GLT-1 and GLAST to enhance glutamate uptake [46, 47], but there have been poor mechanistic experiments to transport riluzole across the BBB to the brain.