In addition to high plasma levels of PLT-released proteins such as thrombospondin-1, platelet factor 4 [44] or sCD40L [45], increased PLT expression of CD62P (P-selectin) and CD40L has been described in SCA patients [46], demonstrating abnormal activation of this blood cell type element. The gene discussed is PF4; the disease is autosomal dominant cerebellar ataxia.