Up to 25% familial DCM and 18% sporadic DCM patients exhibited a titin mutation.[27] In a study that enrolled patients with PPCM to investigate the truncating variants of the titin gene, ∼10% patients shared such genetic mutations.[17] However, little is known regarding the cause of the pathogenic mutation, and titin gene variations are not always disease triggering but rather disease modifying.[27]. Here, TTN is linked to familial dilated cardiomyopathy.