Moreover, pantoprazole treatment significantly inhibited the mRNA levels of JAK2 and STAT3 in three pantoprazole-treated groups in a dose-dependent manner in the CL, CM, and CH groups, indicating that a higher concentration of pantoprazole has a stronger inhibitory effect on the muscle wasting induced by cancer cachexia (Figure 2A-2D). The gene discussed is JAK2; the disease is cancer.