(1) pantoprazole can significantly inhibit the levels of serum IL-6 and TNF-α in cachectic mice, which may induce a local and systemic inflammatory response; (2) the treatment of pantoprazole also suppresses the systemic inflammatory response-induced activation of the JAK2/STAT3 signaling pathway [12]; (3) the inactivation of the JAK2/STAT3 signaling pathway subsequently inhibits the expression of MuRF1 and Fbx32 protein, which can significantly alleviate the progression of tumor cachexia-related muscle atrophy and protein degradation [30]. Here, TNF is linked to neoplasm.