In contrast to the findings that VDR gene polymorphisms seem not related to the esophageal adenocarcinoma (EAC) risk development [21], we previously showed a significantly increased risk of esophageal squamous cell carcinoma associated with VDR rs2107301 T>C polymorphism among patients who were drinking [13]. The gene discussed is VDR; the disease is esophageal squamous cell carcinoma.