In our previous study, we have investigated the correlation of four SNPs VDR rs11568820 G>A, VDR rs1989969 C>T, VDR rs2107301 T>C and VDR rs2228570 C>T with esophageal squamous cell carcinoma development, and found that VDR rs2107301 T>C polymorphism with alcohol drinking enhanced the risk of esophageal squamous cell carcinoma [13]. This evidence concerns the gene VDR and esophageal squamous cell carcinoma.