In the present meta-analysis, the results demonstrated that the VEGF +1612G/A polymorphism was significant correlated with RCC only in allele model (pooled OR = 1.08, 95% CI: 1.00-1.17) and homozygote model (pooled OR = 1.33, 95% CI: 1.02-1.74) (Figure 4). This evidence concerns the gene VEGFA and renal cell carcinoma.