Significant differences were found between VEGF +936C/T polymorphism and RCC risk using allele model: pooled OR=1.16, 95% CI: 1.05-1.29; homozygote model: pooled OR=1.33, 95% CI: 1.08-1.65; dominant model: pooled OR=1.16, 95% CI: 1.02-1.33; recessive model: pooled OR=1.25, 95% CI: 1.02-1.52. The gene discussed is VEGFA; the disease is renal cell carcinoma.