The combined results of all analyses showed that the pooled OR of these six studies was 1.30 (95% CI: 1.18-1.43) for allele model, 1.60 (95% CI: 1.31-1.96) for homozygote model, 1.24 (95% CI: 1.08-1.43) for heterozygote model, 1.31 (95% CI: 1.15-1.50) for dominant model and 1.39 (95% CI: 1.16-1.67) for recessive model, which indicated a strong association between VEGF -2578C/A mutation and RCC susceptibility. Here, VEGFA is linked to renal cell carcinoma.