The combined results of all analyses showed that the pooled OR of these studies was 1.18 (95% CI: 1.05-1.33) for allele model, 1.35 (95% CI: 1.06-1.72) for homozygote model and 1.25 (95% CI: 1.05-1.48) for heterozygote model and 1.27(95% CI: 1.08-1.49) for dominant model, which indicated a significant association between VEGF +405 G/C polymorphism and RCC risk. The gene discussed is VEGFA; the disease is renal cell carcinoma.