AKT1 and breast carcinoma: However, we have also noticed that a positive correlation between Cav-1 and mTOR signalling is reported in literatures, such as a sustained activation of Cav-1 and PI3K/Akt/mTOR signalling cascades by low shear stress in breast carcinoma MDA-MB-231 cells [76], and galectin-1-induced p-mTOR inhibition by Cav-1 siRNA in mouse embryonic stem cells [77].