Another study by Sahani et al. showed that prolonged autophagy activation by starvation restored p62/SQSTM1 by transcriptional up-regulation in mouse embryonic fibroblasts and human hepatocellular carcinoma cells, suggesting that the expression level of p62/SQSTM1 does not always inversely correlate with autophagic activity [28]. Here, SQSTM1 is linked to hepatocellular carcinoma.