This modification seems related to the regulation of MMP2 and SRD5A2 gene expression; Sestito et al. [66] demonstrated that SIRT1 was responsible for STAT3 deacetylation and, according with our results, Lovaas et al. [61] showed that SIRT1 induced an increase of MMP2 gene expression, thus promoting tumor invasion. The gene discussed is MMP2; the disease is neoplasm.