Western blot analysis showed that protein levels of both HDAC1 and YY1 were higher in high-dose sensitive HCC cell lines SMMC-7721 and HUH-7 than that in low-dose sensitive HCC cell lines HEPG2 and BEL-7404 (Figure 2F and Supplementary Figure 1). This evidence concerns the gene HDAC1 and hepatocellular carcinoma.