The nanostructure carrying ATF5 siRNA exertsremarkable RNA-interfering efficiency, increases glioblastoma cell apoptosis andinhibits tumour cell growth both in vitro and in xenograft tumour models.This strategy of targeting the macropinocytosis caused by Ras activationprovides a nanoparticle-based approach for precision therapy in glioblastoma andother Ras-activated cancers. Here, ATF5 is linked to neoplasm.