Finally, siRNA-CaP-rHDL was prepared byincubating siRNA-CaP-LNC with apolipoprotein E3 (ApoE3), which was previouslyconfirmed to be responsible for binding to low-density lipoprotein receptor(LDLR) and low-density lipoprotein receptor-related protein 1 (LRP1) that areexpressed in the BBB, blood–brain tumour barrier (BBTB) and glioblastomacells21, 22, 23, 24, 25. The gene discussed is LDLR; the disease is brain neoplasm.