TSC2 and kidney cancer: We next investigated the mutation data for 24 important genes (TP53, VHL, PBRM1, SETD2, KDM5C, BAP1, NF2, PTEN, ARID1A, MICALCL, STAG2, SLC1A3, CDKN1A, MTOR, MET, SMARCB1, TCEB1, NFE2L2, PIK3CA, MLL3, FH, FLCN, TSC1, TSC2) recurrently mutated in the three TCGA kidney cancer subtypes based on the three TCGA kidney cancer studies17, 22, 24.