AKT1 and neoplasm: Compared to the PBS-treated vehicle control, TMab4-i slightly retarded the growth of SW480 and HT1080 tumours, which was accompanied by reduced phosphorylation of Akt (Fig. 6a,b and Supplementary Figs 10 and 11); this could be attributed to the anti-tumour activity of the RGD10 moiety, through blocking integrin αvβ3- and/or αvβ5-mediated tumour angiogenesis and growth39, 40.