NRAS and neoplasm: However, RT11-i as a single agent exhibited measurable anti-tumour activity via the oncogenic Ras-specific blocking mechanism, showing a ∼46–70% more TGI, when compared to treatment with TMab4-i, in mice harbouring oncogenic KRas mutant SW480 and LoVo tumours as well as NRas mutant HT1080 tumours, but not in those harbouring RasWT tumours (Fig. 6), without systemic toxicity (Supplementary Fig. 10c).